3.- TECHNIQUES FOR SOLUBILITY ENHANCEMENT 3.1.- Physical modifications Particle size reduction5: The drug solubility is related to drug particle size. 30 0 obj PHYSICAL MODIFICATIONS Solubility is a phenomenon which is related to particle size and … /BaseFont /Times#20New#20Roman 33 0 obj /Leading 42 2TherdosePharmaPvt.Ltd,Kukatpally,Hyderabad,AndhraPradesh, India TECHNIQUES FOR SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS: AN OVERVIEW >> an overview on solubility enhancement techniques for poorly soluble drugs and solid dispersion as an eminent strategic approach html full text. of solubility is one of the major challenges for formulation chemists. /LastChar 122 /FontWeight 400 endobj %���� /Subtype /TrueType The techniques of solubility enhancement are categorized as follows: Figure 2: Techniques of solubility enhancement These are the general techniques to enhance solubility. 1 0 obj %PDF-1.5 endobj In 1961, Sekiguchi and Obi 5 developed a practical method whereby many of the limitations with the bioavailability enhancement of poorly water soluble drugs can be overcome. Author: Sandeep Kumar, Pritam Singh Abstract: Solubility is not to be confused with the ability to dissolve or liquefy a substance, since this process may occur not only because of dissolution but also because of a chemical reaction. <>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 30 0 R] /MediaBox[ 0 0 595.32 841.92] /Contents 4 0 R/Group<>/Tabs/S>> CHAITANYA 1Department ofPharmaceutics,BharatInstitute Technology(Pharmacy),Ibrahimpatnam, Hyderabad,AndhraPradesh,India. << << 3.- TECHNIQUES FOR SOLUBILITY ENHANCEMENT 3.1.- Physical modifications Particle size reduction5: The drug solubility is related to drug particle size. endobj 2 0 obj The poor solubility of drug substances in water (less than 1µg/ml) and their low dissolution rate in aqueous G.I.T fluid often leads to J1L,N@,���0e�/��F(D)i���b>Bq3�����6Y�d����c�Ê�i�O� Research Article ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IRBESARTAN BY SOLID DISPERSION TECHNIQUE G. 1ASHWINI KUMAR* , 2RAM KUMAR CHOUDHARY1 AND CH. Consequences of poor aqueous solubility would lead to failure in formulation development. Solubility, Solubility enhancement, Bioavailability, Novel methods, Dissolution. 3 0 obj ;�ྟ�x�������Z��O@���ޮzۄ毃��~�P�*�|���6o�3�Ls� ���лi��N��'m�������~�/a��)=f�k�P�O� /XHeight 250 iͰI��|�Rǰ�س�-RBn��E�qX?ZR��Zcd�l�k�����@b:G�ݡ"9��'����ۊ %G'M���.�0���1{7I�74��e۽1�~ D��W�cN�k�w��V �C)��ɻ�R[�������S�;zk�mARU0�.��Q�1�c��dʽ;�����Ŧ! stream The larger surface area allows greater interaction with the solvent , increasing the solubility. /Length1 438388 /FirstChar 32 /Name /F1 /Ascent 891 TECHNIQUES FOR SOLUBILITY ENHANCEMENT There are various techniques available to improve the solubility of poorly soluble drugs. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug. <> In quantitative terms it is concentration of dissolved solute in a saturated solution at a specific temperature. This method, which was later, termed solid dispersion which involved the formation of eutectic mixture of drugs with /Length 170964 I. NTRODUCTION: Solubility is a property of substance in a particular solvent. @m3�3�X��X,� �����ߞ�㣳�Q��?�T#]ɬ�7�����ގO�&S>�M�r��L�� Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic Effectiveness. �#��%��X^\�Ƚp�6eU�b�U�+E��1�U�6L��S2b)6���������ql�Kzoٍ��:� ]���� �Q��,T�_;N����oC�0>U���}�� �Y-+\��m#����� Ŭ�HA�"zpăsL�^*V���*�`Kp��x��B���f����ҝJ�(��aBʥ�e�>v@���j��bzJx_����I�"�F�5U���%8[�$9�O������i���ʪ"l����X�{@W SOLUBILITY ENHANCEMENT OF POORLY HYDROPHILIC DRUGS BY USING DIFFERENT NEWER TECHNIQUES: A REVIEW Varshney, H. M.1, Chatterjee, A. %PDF-1.5 %���� *1 1Department of Pharmaceutics, Faculty of Pharmacy, Jaipur College of Pharmacy, Jaipur, Rajasthan-302022, India INTRODUCTION According to IUPAC, solubility may be defined as “The analytical composition of a saturated Q_�Zc��w�D���_'�j��IrDJg����4�y�Y����lĠ[籃[ľ'�X-���h�z�/a��h)�� ��7 |@��ʨi��D1N@�JP^��� �T�h�H�C���w��J�(�!Vq�Yӯ��DvL]�)u�t'��֎j�����(�O��y������OO%��ెǹ�ߕ�'9ϙV���V'9;ҏ���z-�A�ܿ�-���S ou���z�� J�o�^>� /Encoding /WinAnsiEncoding /Type /FontDescriptor are practical limitation of these techniques. /AvgWidth 401 sandhiya jatwani*, avtar chand rana, gurpreet singh and geeta aggarwal /Descent -216 There are various techniques for solubility enhancement. >> Techniques Of Solubility Enhancement 1) Particle Size Reduction Conventional methods Micronization Nanosuspension 2)Hydrotropy 3)Cosolvency 4) Solubilization bySurfactants 5)Solid Dispersion The fusion method The solvent evaporation method hot melt … �,���n�z�ɰe���� ]�w��A83��[��7{���;I�m��h_u*B��`Dd�%��ި�X�,� Volume5, Issue1 Various techniques for solubility enhancement: An overview. /Type /Font _I�Y�@�D������W�1���D��8��x�����������Dq�^~������o������8q��U[�DS�8L�y]$l��f0� *��G?i���%��+��*��{1�!�~��R����Jd��tV�E�z��E��:p-=JM��E��58�1π�L�nA����;�`�԰EV��(E��>lZ�v�c�(YV�4v H]i,M�����d+���Vk���Ye���Wr�*�e�ޞ�A�D�6����dZ��d�w#�/���W������������V����L��!�y��5��2Z��ɾ�L�z�}�SK� S�d6��R_B�k��za�D>����i�@r�>r���2��@o_S�?g[tW>�f)'C��S"������9�s�hS�H�m�n�J�_�Q#���p���\0�,��Kt���i�Ϋ�p�,�}��m���2隝"q/ΐ����/qʞ�q9JYƴ�;9�qQG��E�eA~sԲM5k��1�-�D�vO�荒��9'��