All submissions are subject to peer review and allowing the submission of preprint manuscripts does not guarantee publication in any Mary Ann Liebert, Inc., journal. If found to be of potential interest, a formal submission will be encouraged which, after submission, will be sent out for external review as well as internal review by members of the Editorial Board. The supplementary information can provide more detailed information of the pertinent negative and positive findings. Plagiarized manuscripts will be rejected immediately. HGT Clinical Development is an excellent venue for publishing additional topics including production and characterization data of gene and cell therapy products; selected clinical protocols which describe first-in-human applications of cell and gene therapy; and topical issues related to the commercial development of gene and cell therapy products. Materials and Methods and any additional data should be included in a supplementary section. By submitting a manuscript to the Journal, the author(s) agree(s) to each of the above conditions. Other Competing Interests. A pre-submission inquiry regarding an unsolicited review, commentary, or editorial should be submitted to the Editor-in-Chief at wilsonjm@mail.med.upenn.edu. It's publishing house is located in United States. Introduction. With the addition of HGT Clinical Development in 2013, 22 issues in the Human Gene Therapy Program are published annually by Mary Ann Liebert, Inc., 140 Huguenot Street, New Rochelle, NY 10801-5215. Clinical Development articles are pre-clinical articles focusing on pharmacology/ toxicity/ bio-distribution experiments used in the review of proposed clinical trials and contain sufficient information to allow referencing between products within the same technology platform when appropriate. The Office of Foreign Assets Control (OFAC) of the US Department of the Treasury administers and enforces economic and trade sanctions based on US foreign policy and national security goals against targeted foreign countries and regimes, terrorists, international narcotics traffickers, those engaged in activities related to the proliferation of weapons of mass destruction, and other threats to the national security, foreign policy or economy of the United States. In the Methods section, state that informed consent was obtained from subjects (specify written or verbal). This journal has an h-index of 20. When doing so, please refer to this information and data in the presentation of results that appears in the published manuscript. In addition, specific funding organizations have separate agreements and authors should refer to the policies of those specific funding agencies prior to the submission of their manuscript. The Editor-in-Chief and Associate Editors will recuse themselves from participating in the review process of any manuscript in which there is a potential or actual competing interest. Written permission must be obtained from the publisher of the journal or book concerned. SCImago Journal Rank is an indicator, which measures the scientific influence of journals. Any requested changes related to content, or that alter the outcome of a study, will require the approval of the Editor, and may require further peer review. As such, all allegations of misconduct will be referred to the Editor-In-Chief of the Journal who in turn will review the circumstances, possibly in consultation with associate editors and/or members of the editorial board. You can pay by credit card or receive an invoice to be returned with payment or via bank transfer. The accepted version may be placed on: It is used for the recognition of journals, newspapers, periodicals, and magazines in all kind of forms, be it print-media or electronic. (Deposition of a preprint on a preprint server is not considered as prior publication and will not impact consideration of any submitted manuscript.). If work was presented at a conference, supply the name, date, and location of the meeting as a footnote on the title page of the submission. Post-publication changes or alterations to conference abstracts are prohibited. •    500-word limit Include a description of the investigational agent being evaluated. Materials and Methods. The overall rank of Human gene therapy methods is 7005. d. Informed Consent: Include an example of a consent document in Supplementary information, 5. Submissions that describe key technological advances such as techniques for detecting transgene expression, improved vector design, manufacturing advancements, and product testing assays are welcomed. The Liebert Open Access APC does not cover or replace existing publication or author fees. Any archiving of the accepted version for inclusion in subject-based repositories, such as PubMed Central (PMC), should follow the requirements of the funder of the work. Please note that the typical time between acceptance of a paper and page proof distribution is approximately 3-6 weeks depending on the length and complexity of the paper, and the timing of the corresponding author's responses to page proofs. Research Promotion Services Visit the official website of the journal/conference for the call for paper, submission guidelines, notification date, and submission deadlines. Authors funded by these organizations should follow the self-archiving terms and conditions of these separate agreements based on the policies of the specific funding institutions. •    Maximum of two (2) tables and/or figures, Commentaries Finally, a footnote to a reprinted table, or of the legend of a reprinted figure should read, “Reprinted by permission from Jones et al.” and list the appropriate reference. Title. Editors and Reviewers must maintain strict confidentiality of manuscripts during the peer-review process. Study Procedures. Halftones and color should be submitted at a minimum of 300 dpi. If doubt exists whether the research was conducted in accordance with the Helsinki Declaration, the authors must explain the rationale for their approach and demonstrate that the institutional review body explicitly approved the doubtful aspects of the study. This support includes salary, equipment, supplies, honoraria, reimbursement or prepayment for attending symposia, and other expenses. These are usually solicited by the Editorial Board, but we welcome unsolicited submissions of this type. This information should be outlined in the cover letter accompanying the submission, and in a sentence declaring adherence should be included in the Materials and Methods section of the manuscript. Stoneham, MA: Butterworth Publishers, 1988: 205–225. Springer Figures and tables should be supplied in separate files, be labeled clearly, and should be in TIFF or EPS formats. ACM Recognizing the importance of all clinical data in the formative stages of the field, HGT Clinical Development will publish clinical trials of gene and cell therapy including those which are confirmatory or negative; if the clinical trial is novel and/or reports positive data, it should be considered for publication in Human Gene Therapy. We prefer that the total number of tables and figures in the printed manuscript is not greater than six (6).